Objective TDP-43 is deposited as cytoplasmic and intranuclear inclusions in brains of subject matter with frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS). antibodies to ubiquitin and, unlike existing commercially-available anti-TDP-43 antibodies, did not stain normal nuclei. Ultrastructurally, these antibodies labeled abnormal materials of 15 nm diameter, and on immunoblots acknowledged… Continue reading Objective TDP-43 is deposited as cytoplasmic and intranuclear inclusions in brains