Autoimmune associated congenital heart block (CHB) might derive from pathogenic cross-talk between inflammatory and profibrosing pathways. inhibitors from the ET-1 receptors ETb or ETa or by an anti-ET-1 antibody however, not by an isotype control. Exogenous ET-1 induced a profibrosing phenotype, whereas fibroblasts transfected with either ETa or ETb siRNA had been unresponsive towards the… Continue reading Autoimmune associated congenital heart block (CHB) might derive from pathogenic cross-talk