Background Antibodies to citrullinated proteins (ACPAs) certainly are a hallmark of arthritis rheumatoid (RA). RA and precede the starting point of scientific disease by years.4C6 Peptidylarginine deiminases (PAD) are enzymes that catalyze the posttranslational adjustment result of arginine residues to citrulline.7,8 By modifying Dasatinib autoantigens in synovial tissues and alternative sites of inflammation, PAD activity… Continue reading Background Antibodies to citrullinated proteins (ACPAs) certainly are a hallmark of